14 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
tubule of the kidney ... Most cases diagnosed ... respiratory failure • Neurologic ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
cases there are ... splenomegaly, abnormal neurology ... , back pain Haematology ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... vomiting, abdominal pain ... ) Differential Diagnosis ... Maternal Support - Critical ... Liver #Pregnancy #hepatology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... Summary Causes ... Dermatomyositis Clinical ... nephrotoxicity to kidney ... #Management #causes
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... • Fever is the main ... Heart, lung, and kidney ... #Syndrome #Diagnosis ... #Management #Hematology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Guillain-Barre Clinical ... Hands or feet • Pain ... #management #treatment ... #neurology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Caused by splanchnic ... sympathetic + ADH activation ... Diagnosis (Clinical ... Hepatorenal #Syndrome #Hepatology ... #Nephrology #Diagnosis
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Generalized fatigue - ALS ... myasthenia Diagnosis ... immunosuppressants - Meds ... Myasthenia #Gravis #diagnosis ... #management #neurology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Transverse Myelitis - Clinical ... or without back pain ... bouts of HTN Diagnostic ... #management #neurology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
Crisis (SRC) Clinical ... Crisis: 1) Acute kidney ... endothelial cell activation ... , add other BP meds ... #diagnosis #management