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hematology chronic cll leukemia lymphocytic syndrome workup behcet classification erythematosus hemeonc hemophagocytic hlh hodgkins igg4 lupus lymphohistiocytosis phenotypes polychondritis relapsing
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... number of sites of disease ... Treatment • Early ... #hematology #oncology ... #management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... Clinical history ... • "Reactive lymphoid ... #diagnosis #management ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, B-cell lymphoma ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment ... #summary #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... phenomenon (16%) MSK ... Adenocarcinoma Treatment ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... pain • Swan neck/Ulnar ... • Kidney biopsy ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cells can indicate disease ... microglobulin Treatment ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... to large cell lymphoma ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #diagnosis #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... Ischemia, Leukemia, Lymphoma ... Arthritis, AS Treatment ... #management #signs ... #symptoms #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... Viral infection • Lymphoma ... CRP, ANA + • Biopsy ... affected tissue Treatment ... #diagnosis #management
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