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diagnosis management differential algorithm hepatitis cirrhosis hematology causes disease hepatic hyperbilirubinemia indications injury syndrome aclf activation aflp aih albumin autoimmune
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... EmoryGastroHep #ACLF #Acute ... Failure #Cirrhosis #Hepatology ... #gastroenterology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Mixed - Check Acute ... hepatocellular injury • Bilirubin ... week • Direct bilirubin ... Elevation: • Bilirubin ... #differential #Hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
fold elevation, Bilirubin ... fold elevation, Bilirubin ... and hemorrhage Acute ... but variable ++, Bilirubin ... Disease #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... hepatocellular injury • Bilirubin ... week • Direct bilirubin ... Elevation: • Bilirubin ... diagnosis #algorithm #hepatology
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
Cell Disease Acute ... Supportive with treatment ... liver failure ... Liver transplant ... Hepatobiliary #hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
immunosuppression • Acute ... injury (INR > 2, bilirubin ... > 3 mg/dL) or acute ... liver failure ... Indications #management #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
and unconjugated bilirubin ... and excretion of bilirubin ... —100-fold with acute ... liver failure; ... LiverFailure #Hepatic #Hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... birth with serum bilirubin ... associated with bilirubin ... #hepatology #diagnosis ... #gastroenterology
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
paracentesis (>5 liter ... ) - 8g per liter ... ascites removed • Acute ... Management #Cirrhosis #treatment ... #hepatology
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