37 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Calculate R-Value ... #differential #Diagnosis ... #algorithm #gastroenterology ... #hepatology
Shotgun Laboratory Testing for Severe Acute Livery Injury

https://www.journalofhospitalmedicine.com/jhospmed/article/143598/hospital-medicine/ammonia-levels-and-hepatic-encephalopathy-patients-known

#TWDFNR #Testing #Laboratory #LiverInjury #Diagnosis #Workup #Hepatology #EBM #ChoosingWisely
Shotgun Laboratory ... for Severe Acute Livery ... TWDFNR #Testing #Laboratory ... #LiverInjury #Diagnosis ... #Workup #Hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... LFTs) - Normal Values ... #Tests #LFTs #Laboratory ... #Values #Interpretation ... #diagnosis #hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Defects, Drugs, Liver ... Hypophostphatemia Laboratory ... #hematology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... • R value = (ALT ... Transaminitis #diagnosis ... #differential #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... disease, liver ... Failure #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... , Metastasis #Liver ... #differential #diagnosis ... #comparison #table ... #appearance #hepatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
- Differential Diagnosis ... MRCP, ERCP, liver ... #Differential #Diagnosis ... #Algorithm #gastroenterology ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis ... #hepatology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
inhibitor • Liver ... Thromboplastin #laboratory ... #hematology #diagnosis