14 results
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Algorithm for the ... Evaluation and ... of Sickle Cell Crises ... Clinical Manifestations ... Diagnosis #Management #Hematology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm
Congenital
Medications
 • Anticonvulsants
 • Antibiotics
 • Antithyroid
 • Antihypertensive
Causes of Isolated ... Differential Diagnosis Algorithm ... Infection • Epstein-Barr ... Virus • Cytomegalovirus ... #Causes #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... Tuberculosis • Epstein-Barr ... #causes
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... CMV) • Epstein-Barr ... virus (EBV) • ... #oncology #hematology
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Anemia is described ... Pancytopenia is a hematologic ... well as varying clinical ... These causes could
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Infections+++: Virus ... inhibitors under evaluation ... treatment #summary #rheumatology
General Approach to Anemia - Differential Diagnosis Framework
1) Check reticulocyte count to determine if hypo/hyper-proliferative
2) Exclude
General Approach to Anemia ... ) 3) Use MCV & clinical ... guide further evaluation ... differential #diagnosis #hematology ... #algorithm #reticulocyte
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... likelihood of negative clinical ... count on initial evaluation ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... infections (Epstein-Barr ... hypogammaglobulinemia #immunology #hematology
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary

WHAT?
 • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
disease of unknown cause ... CLINICAL: • Physical ... • An evaluation ... • Normocytic anemia ... Diagnosis #Management #Rheumatology