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hematology anemia differential workup approach atlas bloodcell causes classification cold deficiency disease ferritin macrocytic microcytic microscopy morphology nomenclature rbc red
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... Diagnosis: • hemolytic ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... Agglutination - Cold agglutinins ... Consider RBC membrane disorder ... #hematology #testing
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
- Differential Diagnosis ... Algorithm Labs ... TSAT, sTfR • Blood ... extravascular) hemolysis ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... in peripheral blood ... High in acute blood ... loss, hemolysis ... (BM) ablative disorders
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... MCH, MCHC, Serum Iron ... Reticulocytes • Iron ... #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... , Thalassemia, Iron ... disease, McLeod blood ... Unstable hemoglobin disorders ... #differential #diagnosis
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