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differential management agglutinin anemia antibodies arthritis cold erythematosus hemolytic joint leukemia lupus monoarthritis monoarticular msk myopathy myositis oligoarticular oncology patterns
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... Lymphoproliferative Disorders ... #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... Mechanical/degenerative disorders ... constitutional symptoms ... Rheumatologic Disease ... #MSK #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... infection, autoimmune ... - Mycoplasma, EBV ... chills, flank pain ... hemolytic #anemia #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Non-autoimmune ... rheumatologic diseases ... Arthritis: • Joint pain ... Induced Lupus: • Symptoms ... #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... • Tumor lysis syndrome ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... claudication, visual ... • Progressive symptoms ... and GN Anti-GBM ... #Rheumatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc - Autoimmune ... erythematosus (SLE ... cell lymphoma Pathophysiology ... the systemic symptoms ... #management #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... disorder) Who ... Sudden onset of pain ... cases such as: • SLE ... Polychondritis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... substantial muscle pain ... RP-ILD), dermato-rheumatologic ... • Proximal + distal ... Myositis #Myopathy #rheumatology
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