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differential agglutinin antibodies arthritis cold erythematosus hemolytic joint leukemia lupus management monoarthritis monoarticular msk oligoarticular oncology patterns polyarthritis polyarticular polychondritis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... Lymphoproliferative Disorders ... #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... Mechanical/degenerative disorders ... constitutional symptoms ... Rheumatologic Disease ... #MSK #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... infection, autoimmune ... - Mycoplasma, EBV ... chills, flank pain ... #hematology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
rheumatologic diseases ... Arthritis: • Joint pain ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... disorder) Who ... Sudden onset of pain ... cases such as: • SLE ... Polychondritis #rheumatology
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