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differential hemolytic oncology classification testing ana antinuclear arthritis autoimmune chronic cll cold elevatedmcv extravascular gap globulin hemolysis hodgkins intravascular laboratory
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Syndrome (CAS): ... anemia • Cold ... Blood smear - RBC ... #anemia #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
pylori test (GI symptoms ... anti-phospholipid antibodies ... changes), high MCV anemia ... #Causes #Workup ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold agglutinins ... membrane disorder ... #Algorithm #workup ... #hematology #testing
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... SLE), Sjogren's Syndrome ... Lymphoproliferative Disorders ... ANA #patterns #rheumatology ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... . primary cold agglutin ... disorders, Mycoplasma ... #hematology #anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... erythematosus, ... Symptoms (Sx) in ... C-ANCA) pattern: antibodies ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... age 70 years Symptoms ... Myeloproliferative Disease ... #diagnosis #hematology
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