18 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... pylori test (GI symptoms ... anti-phospholipid antibodies ... #Causes #Workup ... #hematology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... SLE), Sjogren's Syndrome ... Lymphoproliferative Disorders ... ANA #patterns #rheumatology ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #hematology #anemia
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... • Non-autoimmune ... rheumatologic diseases ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Schistocytes, thrombocytopenia ... membrane disorder ... elliptocytosis, autoimmune ... #Algorithm #workup ... #hematology #testing
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral infection, autoimmune ... Blood smear - RBC ... (older) • Autoimmune ... hemolytic #anemia #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Lymphocytic Leukemia (CLL ... leukemia in adults • Disorder ... chemotherapy for low-risk disease ... 3) Monoclonal antibodies ... Leukemia #oncology #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... cells can indicate disease ... lymphoproliferative disorders ... #workup #oncology ... #hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... diseases: - 10% ... lupus erythematosus ... #types #classification ... #rheumatology #
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
mesothelioma, etc - Autoimmune ... systemic lupus ... erythematosus (SLE ... symptoms Histopathological ... #management #rheumatology