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anemia oncology agglutinin algorithm biliary chronic cirrhosis cll cold erythematosus extravascular gap globulin hemolysis hepatopulmonary hodgkins intravascular leukemia lupus lymphocytic
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... decreased PLT count: CBC ... ), HBsAg/anti-HBc ... Diagnosis #Causes ... #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
hypertension • Unusual RBC ... acanthocytes - Consider RBC ... membrane disorder ... #workup #hematology ... #testing
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... lymphoproliferative disorders ... • Intrinsic RBC ... #differential # ... diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... Signs and Symptoms ... bile ducts Differential ... #cholangitis #diagnosis ... #workup #hepatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #symptoms #testing ... #workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... Positive Coombs testing ... Blood smear - RBC ... #hematology #diagnosis
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
a gas exchange disorder ... Caused by intrapulmonary ... Arterial blood gas (ABC ... #diagnosis #management ... #treatment #hepatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... Induced Lupus: • Symptoms ... titers > 1:80 • CBC ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis: Systemic ... Symptoms (Sx) in ... Lab Tests: • CBC ... #diagnosis #rheumatology ... #classification
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Lymphocytosis on CBC ... cells can indicate disease ... #workup #oncology ... #hematology
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