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differential aclf aih anemia causes chemistry cirrhosis cll common cvid dili druginduced failure gap gastroenterology globulin hypogammaglobulinemia immunodeficiency immunology interpretation
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #Acute #algorithm ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology ... #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular ... : Autoimmune hepatitis ... #injury #hepatitis ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... dechallenge • Acute ... steatosis • Autoimmune ... #Injury #Diagnosis ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... > 3 • Chronic ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... - Symptoms of chronic ... injury, though ... #Diagnosis #Management ... #Hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... • ↓ WBC • ↓ ... #Anemia #oncology ... #hematology #diagnosis ... #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... Lymphoma or other cancers ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Pure red cell aplasia ... ’s lymphoma or acute ... #workup #oncology ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Sarcoidosis) • Liver ... hepatitis, PBC, ... gastric tumors • Hematology ... #hematology
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