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lymphocytic agglutinin classification cold cvid erythematosus extravascular gap globulin hemeonc hemolysis hypogammaglobulinemia immunodeficiency immunology intravascular lupus mds myelodysplasia myelodysplastic protein
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(DIC) - HELLP ... syndrome - ... uremic syndrome ... ) (e.g. lupus, CLL ... diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Richter’s Syndrome ... , Hodgkin’s lymphoma ... • Sezary syndrome ... #Leukemia #diagnosis ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphoma #Leukemia ... #Hematology #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Lymphoma - Clinical ... platelets - WBC ... #lymphoma #diagnosis ... classification #hematology ... #oncology #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... lymphoma (Richter ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... symptoms - most common ... Diagnosis: • hemolytic ... #hemolytic #anemia ... #hematology #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Easy or unusual bruising ... Most common cytopenia ... Cell Leukemia ... #diagnosis #hematology ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
' syndrome in the ... lymphoproliferative syndrome ... Shrinking lung syndrome ... lymphoma and leukemia ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... anemia • Other ... #diagnosis #hematology
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