10 results
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... mediated BEC injury ... #Cirrhosis #Pathophysiology ... #hepatology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Vmphocytosis on routine CBC ... chemotherapy for low-risk disease ... fludarabine) 3) Monoclonal ... #Leukemia #oncology ... #hematology #hemeonc
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... + distinctive primary ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... cells can indicate disease ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Cirrhosis (PBC) ... Pathophysiology ... : • T lymphocyte ... diagnosis #workup #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... hepatitis: < 1 • Cirrhosis ... • Gilbert's syndrome ... #hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
15% of AIHA Primary ... Cold Agglutinin Syndrome ... lymphoid malignancy (CLL ... Blood smear - RBC ... hemolytic #anemia #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... +Organomegaly+↑RBC ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
of Acute Liver Injury ... obstruction, HELLP Syndrome ... Malignancy, 1° PBC ... Causes #Acute #algorithm ... #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
changes (POEMS syndrome ... : Cirrhosis, ETOH ... autoimmune hepatitis, PBC ... gastric tumors • Hematology ... differential #diagnosis #hematology