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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
malignancy Pathophysiology ... occurs secondary ... GH stimulates liver ... Beckwith Wiedemann syndrome ... Diagnosis and Workup
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Classified among the secondary ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Management #Hematology ... #Rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... disease • Liver ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
other diseases • Secondary ... vasculitis: 10%-16% Liver ... primary biliary cirrhosis ... #Rheumatology # ... Diagnosis #Management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Sarcoidosis) • Liver ... disease: Cirrhosis ... gastric tumors • Hematology ... differential #diagnosis #hematology