10 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Dermatomyositis Erythema chronicum ... • Rheumatic fever ... Antiphospholipid-antibody syndrome ... #rashes #differential ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... - Hemolytic anemia ... Anticoagulants (Warfarin ... deficiency • Liver ... #Diagnosis #hematology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Renal Failure • Liver ... Neoplastic / Hematologic ... • Anemia • ... Malignancy Infectious ... Fatigue Syndrome
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Hematologic malignancy ... (elevations of liver ... Bone Marrow - Anemia ... #differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Eosinophilia, asthma, chronic ... tract, and often causes ... mucositis - Rash ... #diagnosis #rheumatology ... #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Disease Classification ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, mucositis • Rash ... Eosinophilia, asthma, chronic ... MPO > PR3 60/ GPA ... tract, and often causes ... #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
gammopathy, and skin ... changes (POEMS syndrome ... Include: • Viral infections ... Sarcoidosis) • Liver ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Tenderness → Consider infectious ... ) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... statins - probably caused