9 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... • Rheumatic fever ... Antiphospholipid-antibody syndrome ... #rashes #differential ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... - Hemolytic anemia ... Anticoagulants (Warfarin ... deficiency • Liver ... #Diagnosis #hematology
Pustular Skin Lesions - Differential Diagnosis Framework

What are pustules?
• Pustules < 5-10 mm + pus
• Material
- Differential ... Diagnosis Framework ... Generalized itchy rash ... Pustules + Fever ... #Diagnosis #Dermatology
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
: • Syndrome of ... Hematologic malignancy ... (elevations of liver ... Bone Marrow - Anemia ... #differential #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Disease Classification ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
mucositis - Rash ... to exclude are infections ... Vasculitis: • Fevers ... #diagnosis #rheumatology ... #classification
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Petechial or purpuric rash ... SLE], AOSD) • Infection ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... , mucositis • Rash ... MPO > PR3 60/ GPA ... #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
gammopathy, and skin ... changes (POEMS syndrome ... Include: • Viral infections ... Sarcoidosis) • Liver ... #diagnosis #hematology