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diagnosis differential hepatology injury anemia chemistry classification drug druginduced gastroenterology hepatitis idiosyncratic induced interpretation liverenzymes management mcv rvalue transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... or symptoms of liver ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... e.g. ascites), Chronic ... Injury #Diagnosis #Algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... function may be abnormal ... > 2 • NASH, Chronic ... #hepatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Differential Diagnosis Algorithm ... Disease Normal ... Renal Disease, Liver ... #Causes #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology ... transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... disease US — Normal ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
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