18 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Systemic lupus erythematosus ... Differential #Diagnosis #Hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Myelodysplastic Syndromes ... Liver Function Tests ... Liver Function Tests ... • Liver Disease ... Algorithm #Causes #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
WHAT test - Wrist Hyperflexion and Abduction of the Thumb 

The wrist is hyperflexed and the
WHAT test - Wrist ... Thumb The wrist ... PhysicalExam #clinical #video ... #sports #msk #orthopedics ... #rheumatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... , Drugs, Liver Disease ... Defects: Sickle cell anemia ... Laboratory Tests ... Differential #Diagnosis #hematology
Eichhoff's Test in de Quervain's Tenosynovitis

1) Patient makes a fist with fingers wrapped around the thumb
2)
ulnar deviates the wrist ... Tenosynovitis #clinical #video ... physicalexam #sports #msk ... #orthopedics #rheumatology ... #wrist
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus erythematosus ... with leukopenia, anemia ... Liver function tests ... Diagnosis #Management #Hematology ... #Rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Demyelinating syndromes ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... SLE #systemic #erythematosus ... symptoms #diagnosis #rheumatology
Eichhoff's Test in de Quervain's Tenosynovitis

The Eichhoff test is used to assess for de Quervain's tenosynovitis,
Eichhoff's Test ... Video via @asaibrahim ... Tenosynovitis #clinical #video ... physicalexam #sports #msk ... #orthopedics #rheumatology