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diagnosis associations autoantibodies lupus activation ana antibodies antinuclear calcium connectivetissuediseases ctild deposition differential diseases druginduced erythematosus gout hematology ild inopressors
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-histone - Drug-induced ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... #diagnosis #table ... #rheumatology #
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... rheumatoid arthritis SLE ... #Differential #Comparison ... #Table #Pulmonary ... #Rheumatology #
Shock and Vasoactive Drugs 1) Determine type and etiology of shock • Distributive: Sepsis, Anaphylaxis, Neurogenic
Failure, Valvular Disease ... pharmacology ... #pharmacology # ... inopressors #diagnosis #management ... #comparison #table
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
joints (shoulders, wrists ... • Underlying disease ... • Metabolic syndrome ... #Gout #Comparison ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... : Chronic disease ... #comparison #table ... #rheumatology # ... diagnosis #management
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... (60-70%) & drug-induced ... overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
joints (shoulders, wrists ... often involves the wrists ... Crowned Dens Syndrome ... #Rheumatology # ... diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... erythematosus [SLE ... ) • Sepsis • Drug-induced ... #Diagnosis #Management ... #Hematology #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... lubricants • Pharmacologic ... #Rheumatology # ... Diagnosis #Management
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