12 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... chain IIA • Thrombocytopenia ... #Defects #comparison ... #table #differential ... #diagnosis #hematology
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... distinction has HUGE treatment ... and first-line treatment ... #Comparison #Diagnosis ... #Table #Hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
aggregation to all ... 1 or Type 3) — differentiate ... Gplb receptor • Thrombcytopenia ... #disorders #hematology ... #hemepath #differential
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
: - Catch-all term ... red-flags to exclude dermatologic ... #Diagnosis #Dermatology ... Targetoid #Algorithm #Differential ... #Ddxof
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... - Differential ... not required in all ... #Differential # ... Causes #Workup #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... Findings in DIC: • Platelet ... - Platelet rich ... + Bleeding Treatment ... diagnosis #causes #treatment
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced Thrombocytopenia ... ♀, ↑Age, ESRD Pathophysiology ... Management: • D/c all ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... factor (GCSF) treatments ... blood count with differential ... Syndromes #diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Arterial Thrombosis - Differential ... considered in all ... Heparin-induced thrombocytopenia ... Venous #Arterial #pathophysiology ... #hematology #differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential ... Renal Failure Treatment