15 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... twitter.com/AmyChung #AntiCoagulation ... #Pharmacology #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Sequestration Disordered ... - Acquired • Anticoagulation ... #Bleeding #Bruising ... Algorithm #Causes #Hematology
Beta-Blockers in Cirrhosis
 • Pathophysiology
 • Indications:  Prevention of decompensation, Prevention of first variceal bleeding,
Beta-Blockers in Cirrhosis ... • Pathophysiology ... first variceal bleeding ... #BetaBlockers #Cirrhosis ... #hepatology #management
Disorders of the Hepatic and Mesenteric Circulation

Platelets in Cirrhosis
Hypercoagulability in Cirrhosis
Bleeding in Cirrhosis
Portal Vein Thrombosis (PVT)
Mesenteric
Disorders of the ... Platelets in Cirrhosis ... Bleeding in Cirrhosis ... #Circulation #Disorders ... #Hepatology #Gastroenterology
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Normal PT (INR) - Bleeding ... PT (INR) - No Bleeding ... Algorithm #Causes #Hematology ... #coagulation #disorders
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Thrombosis and Bleeding ... #Thrombosis #Bleeding ... #Clot #Cirrhosis ... #Pathophysiology ... #Hepatology #Liver
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... LMWH, warfarin, DOACs ... Malignancy, Autoimmune disorders ... EricsMedicalLectures/ #Coagulation ... comparison #diagnosis #hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... lead to severe bleeding ... hemorrhage, while under-coagulation ... decisionaid #cardiology #hematology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
at high risk of bleeding ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Cancer #Algorithm #Anticoagulation ... #Management #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... Findings: • Bleeding ... protein C and S Pathophysiology ... Findings: • Bleeding ... treatment #management #hematology