8 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... procedures - Infection ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... primary hematologic disorder
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... autoimmune hemolytic anemia ... and M panel Management ... DDX - Other causes ... hematology #diagnosis #management
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
Ketosis Disorders ... IVF or PO): The pt ... Glucosuria causes ... differential #diagnosis #management ... #endocrinology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Neutropenia - recurrent infections ... and petechiae Causes ... Idiopathic • Infections ... • ↓ WBC • ↓ PLT ... hematology #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dysfunction, and/or disorders ... wt loss • If anemia ... leukopenia and/or low pit ... Deficiency #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
SLE], AOSD) • Infection ... with leukopenia, anemia ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Syndrome #Diagnosis #Management
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... hematology #oncology #management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... and pernicious anemia ... positive in 2/3 of pts ... limb or joint disorders