6 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Hyperbilirubinemia • Elevated ... Blood smear - RBC ... younger pts) Differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... #Differential # ... Diagnosis #Algorithm #workup
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... schistocytes, nucleated RBCs ... immune hemolytic anemia ... count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Quincke's Pulse in a patient with a normal echocardiogram (non-valvular)

A 70 y/o man presents with new
100 mm Hg), and elevated ... Sent for RHC to ... Workup for cause ... highest on my differential ... Fingernails #Nailbed #Cardiology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... Inflammatory marker elevated ... Immunohistochemical studies (to differentiate
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Elevated Globulin ... Albumin > 4) Work-up ... autoimmune hepatitis, PBC ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential