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diagnosis differential hemolytic oncology algorithm classification cold disease extravascular gap globulin hemolysis hodgkins intravascular lymphoma management mds myelodysplasia myelodysplastic platelet
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Positive Coombs testing ... Blood smear - RBC ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... changes), high MCV anemia ... or if a primary hematologic ... #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold agglutinins ... membrane disorder ... Diagnosis #Algorithm #workup ... #hematology #testing
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. primary cold agglutin ... lymphoproliferative disorders ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... caused by blood ... formed or don’t work ... Workup: • Complete ... Syndromes #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... classification #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Connective tissue disorders ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology
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