12 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... changes), high MCV anemia ... unclear, or if a primary ... #Workup #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
and Primary Causes ... renal failure/uremia ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... #generalized #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... usually IgM) (e.g. primary ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... Scoring system: ... • Neutropenia, anemia ... Leukemia #diagnosis #workup ... #oncology #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
15% of AIHA Primary ... Cold Agglutinin Syndrome ... Positive Coombs testing ... Blood smear - RBC ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Workup: • Complete ... Treatment: Goals: Treating ... #diagnosis #hematology
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... frequently affected systems ... Better call hematology ... up EPO levels Primary ... #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Pruritus - No Primary ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... Pruritus #secondary #systemic ... Diagnosis #Algorithm #causes
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... the context of primary ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... Screening Tests for All ... the presence of anemia ... Arthritis #laboratory #workup