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Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
autoantibodies (pernicious anemia ... intrinsic factor, IF) Clinical ... Worsening macrocytic anemia ... wt loss • If anemia ... - CBC, PBS - anemia
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... , Anemia • Prevalence ... Crohn's > UC Anemia ... Monitor & correct B12 ... (B12, MMA) for
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
form of Vitamin B12 ... - Vitamin B12 ... converts vitamin B12 ... The classic clinical ... of pernicious anemia
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Phosphatase Of Clinical ... Neuropathy ALP is critical ... • Pernicious anemia ... /B12 deficiency
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... E - Haemolytic anaemia ... • Thiamine B1 ... • Riboflavin B2 ... gestation • Vitamin B12
Medications for the Management of Anemia TREATMENT OF ANEMIA - Cyanocobalamin/B12 - Erythropoietin/epoetin alfa - Darbepoetin alfa
Management of Anemia ... TREATMENT OF ANEMIA ... Cyanocobalamin/B12 ... OF SICKLE CELL ANEMIA ... Pentoxifylline #Anemia
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... Iron deficiency anemia ... - Anemia of chronic ... inflammation - Anemia ... disease - Vitamin B12
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... and a vitamin B12 ... elevated, but anemia ... megaloblastic anemia ... that occur with B12
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... - Low Serum B12 ... • Pernicious Anemia ... - Low Serum B12 ... • Rule out B12
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin B12 ... Stomach: Pernicious anemia ... pylori infection, B12 ... BrighamChiefs #Vitamin #B12
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