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diagnosis causes hematology algorithm cobalamin dementia geriatrics macrocytic management pancytopenia rbc workup aafp abg acid acidbase acidosis anosmia approach atlas
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... - Coagulation disorder ... gestation • Vitamin B12 ... #differential # ... signs #symptoms #nutrition
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... • B12/Folate ... Deficiency • Aplastic ... • RBC Membrane Disorder ... #Classification
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Algorithm - Iron deficiency ... disease - Vitamin B12 ... and/or folate deficiency ... Probable bone marrow disorder ... hematology #diagnosis #differential
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... (>100 fL) • B12 ... Deficiency • ... #MCV #Classification ... #Differential #
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... • Dietary Deficiency ... • Small Bowel Disorder ... and Folate Deficiency ... #elevatedMCV #Differential
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
of Low Vitamin B12 ... Levels Low vitamin B12 ... antagonists #VitaminB12 ... #deficiency #low ... #cobalamin #differential
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Iron metabolism disorders ... #Causes #differential ... #diagnosis #anemia ... #nutrition
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Macrocytic RBC: Vitamin B12 ... or Folate deficiency ... Unstable hemoglobin disorders ... RBC #Morphology #differential
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