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management differential syndrome guillain treatment algorithm alkaline aplastic arteritis evaluation falls fatigue gbs gca geriatrics giantcell guillainbarre hematology hepatology hyophosphatasia
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Phosphatase Of Clinical ... Most cases diagnosed ... • Pernicious anemia ... /B12 deficiency ... Phosphatase: • Other causes
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Motor Nerves: ALS ... Poliomyelitis, Guillain-Barre ... : Acid maltase deficiency ... #differential #diagnosis ... #neurology
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Pathophysiology ... Clinical Features ... Paresthesias: Hands ... Diagnosis: • ... management #treatment #neurology
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... & Fe Sucrose > alt ... restricted diet/deficiency ... /other causes • ... IBD #Algorithm #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... CMV) • Epstein-Barr ... oncology #hematology #diagnosis
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Incidence: 1 to 2 cases ... transplantation CLINICAL ... complete paralysis of all ... the underlying pathophysiology ... #management #neurology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... Diagnosis = clinical ... variably: On one hand ... systemic complaints- anemia ... identifies 85 to 95% of cases
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Transverse Myelitis - Clinical ... • Infectious causes ... • Nutritional Deficiency ... #management #neurology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... and pernicious anemia ... Person Syndrome Pathophysiology ... Clinical Manifestations ... Management #treatment #neurology
Evaluation of Recurrent Falls Core Concept: Maintaining an upright posture requires the integrated function of multiple systems. Disruption in
embolism - Severe anemia ... e.g., diabetic, B12 ... deficiency) ... Recurrent #Falls #Diagnosis ... Evaluation #Geriatrics #Neurology
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