19 results
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... Check for IF ab Treatment ... #Cobalamin #Deficiency
Korsakoff Syndrome
Clinical Findings:
 • Confabulation: Usually initial phase of the disease
 • Anterograde amnesia: Memory impairment
Korsakoff Syndrome Clinical ... presentation of Thiamine deficiency ... Encephalopathy Treatment ... Korsakoff #Syndrome #neurology ... #diagnosis
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... restricted diet/deficiency ... /other causes • ... IBD #Algorithm #diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... Treatment: ... oncology #hematology #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... Most cases diagnosed ... • Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... Diagnosis = clinical ... variably: On one hand ... systemic complaints- anemia ... Treatment of GCA
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
perfusion - shock->treatments ... malignancy, or thiamine deficiency ... before beginning treatment ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Nutritional: vitamin B12 ... or folic acid deficiency ... • Copper deficiency ... Myelodysplastic #Syndromes #diagnosis
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Hematologic disease caused ... Incubation period: 3-12 ... Lutzomyia verrucarum Clinical ... severe hemolytic anemia ... TREATMENT: ​• Acute
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
Without treatment ... soles in 50% of cases ... similar to those of B12 ... deficiency. ... Latent #Tertiary #Diagnosis