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diagnosis differential hematology management algorithm vitaminb12 cobalamin elevation hepatology nephrology oncology pancytopenia pathophysiology signs symptoms syndromes aafp abnormal acidosis alkaline
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Deficiency States ... B12 - Anaemia, ... #Deficiency #differential ... signs #symptoms #nutrition
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Stomach: Pernicious anemia ... BrighamChiefs #Vitamin ... #B12 #Deficiency
Micronutrient Deficiencies After Gastric Bypass Fat-Soluble Vitamins: • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
Folate - Macrocytic anemia ... • Vitamin B12 ... - Macrocytic anemia ... Minerals: • Iron - Anemia ... cognitive dysfunction, anemia
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... elevated, but anemia ... B12 deficiency ... megaloblastic anemia ... Macrocytosis #Macrocytic #Anemia
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin ... B12 • Folate deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... Megaloblastic: Vitamin ... B12 deficiency, ... differential #diagnosis #causes
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... , or folate deficiency ... Hypertriglyceridemia • Uremia ... • Hemolytic anemia ... glycosylation • Vitamin
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Polyphenol / tannins, ↓ Vitamin ... #Causes #differential ... #diagnosis #anemia ... #nutrition
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
Inhibited Pathway caused ... - Vitamin B12 ... B12 deficiency. ... The classic clinical ... of pernicious anemia
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