14 results
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... • Thiamine B1 ... Wernicke-Korsakoff syndrome ... gestation • Vitamin B12 ... #differential #diagnosis
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency

Wernicke's encephalopathy is a neurological condition due to longstanding
thiamine (vitamin B1 ... and retrograde amnesia ... #vitaminB1 #B1 # ... #diagnosis #comparison ... #neurology
Wernicke Encephalopathy - Acute Thiamine (B1) Deficiency 
Clinical Diagnosis - Caine Criteria (2 out of 4):
Acute Thiamine (B1 ... ) Deficiency Clinical ... Encephalopathy #Thiamine #B1 ... #Deficiency #diagnosis ... #criteria #neurology
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management
Diagnosis - Caine Criteria (2 of
Encephalopathy - Acute B1 ... development of Korsakoff syndrome ... (chronic B1 deficiency ... Encephalopathy #B1 ... #neurology #nutrition
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
1) Clinical diagnosis ... Whipple, vitamin deficiency ... Aphaso-apraxo-agnosia syndrome ... Differential #Subtypes #Classification ... #Workup #Diagnosis
Korsakoff Syndrome
Clinical Findings:
 • Confabulation: Usually initial phase of the disease
 • Anterograde amnesia: Memory impairment
Korsakoff Syndrome ... Clinical Findings ... • Anterograde amnesia ... presentation of Thiamine deficiency ... #neurology #diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... oncology #hematology #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Nutritional: vitamin B12 ... or folic acid deficiency ... Workup: • Complete ... #diagnosis #hematology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... endocrine: Vitamin B12 ... deficiency • ... dystrophies Work ... #neurology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... Most cases diagnosed ... • Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic