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diagnosis differential management hematology oncology syndromes acidosis alkaline alp aplastic beriberi cobalamin crrt dementia elevation geriatrics hepatology hyophosphatasia lactic low
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Beri-beri, Wernicke-Korsakoff ... gestation • Vitamin B12 ... signs #symptoms #nutrition
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations Causes of Thiamine Deficiency: • Poor intake: - Diets
Framework and Clinical ... Manifestations Causes ... Increased pyruvate & lactate ... - Increased Lactate ... syndromes #beriberi #nutrition
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... Causes of Lactate ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency ... #typea #typeb #classification
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... #Cobalamin #Deficiency ... diagnosis #management #nutrition
Major neurocognitive disorders (MNCD): Diagnosis and workup 1) Clinical diagnosis Cognitive impairment + loss of autonomy 2)
1) Clinical ... Whipple, vitamin deficiency ... Alzheimer - 1st cause ... - Progressive amnesia ... Differential #Subtypes #Classification
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... propylthiouracil) - β-lactam
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Phosphatase Of Clinical ... • Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic ... Phosphatase: • Other causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... Workup: • Complete
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... antibodies • Nutritional ... Deficiency: - ... Vitamin B12, E, ... diagnosis #management #neurology
Renal Replacement Therapy (RRT) - ICU One Pager Summary Indications (AIEOU): • A: Acidosis (usually severe metabolic)
electrolytes, bicarbonate/acetate ... Dialyzer is rigid case ... (Sustained low efficiency ... daily dialysis): ~12 ... RRT #managment #nephrology
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