8 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
with Pancytopenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
evaluation of macrocytic ... the most likely cause ... recovery also causes ... of the initial work-up ... deficiency.
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
MCV 80-100 fl) & macrocytic ... Pancytopenia is ... hemoglobin of less than 12 ... well as varying clinical ... These causes could
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... : • Worsening macrocytic ... diagnosis #management #nutrition
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
bone marrow + pancytopenia ... Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Platelet Disorders • Nutritional ... : vitamin B12 or ... Workup: • Complete
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... • Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic ... Phosphatase: • Other causes
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... • Infectious causes ... antibodies • Nutritional ... Deficiency: - ... diagnosis #management #neurology