39 results
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Primary Adrenal ... Serum DHEAS Diagnosis ... patches on the skin ... #endocrinology ... #diagnosis #signs
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
hypotension - Nausea ... Autoimmune thyroid disease ... disorders: - Pale skin ... Insufficiency #Signs ... #Symptoms #Adrenal
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Generalized Differential Diagnosis ... Causes == Primary ... BUN: • Chronic renal ... #generalized #dermatology ... #Algorithm #causes
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune disease ... thickening Signs ... and Symptoms: ... Hepatic: PBC (primary ... #diagnosis #signs
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Intestine - Other causes ... Pregnancy - Renal ... symptoms - Pain ... - Drugs - Primary
Adrenal Insufficiency - Diagnosis and Management Summary
Primary Adrenal Insufficiency:
Most Common Cause in the US: Autoimmune Adrenalitis
Other
Management Summary Primary ... or metastatic disease ... ketoconazole, etomidate) Symptoms ... , infiltrative diseases ... #Management #Endocrinology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... failure PBC Signs ... and Symptoms: ... Examination: • Skin ... #workup #hepatology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... cold & mottled skin ... pathophysiology #genetics #endocrinology ... #peds #pediatrics
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
Hypercortisolism - Diagnosis ... , oral cavity) Caused ... not a feature of primary ... #signs #symptoms ... #endocrinology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Symptoms ... Primary (essential ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... hematology