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diagnosis differential algorithm management leukemia causes chronic cll hemeonc hemolysis lymphocytic macrocytic morphology agglutinin aplastic bacilliformis bandemia bartonella bloodcell bodies
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
: Vitamin B12 or ... Bite Cell RBC: G6PD ... Target Cell RBC ... differential #diagnosis #hematology ... #microscopy #atlas
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... Atlas • Microcytic ... spherocytosis, Hemolytic ... - Sickle cell anemia ... #differential #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... Consider sickle cell ... Diagnosis #Algorithm #workup ... #hematology #testing
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... , Hemolytic anemia ... : Hemoglobin H disease ... Thalassemia, Sickle cell ... Bodies #diagnosis #hematology
Treatments for Sickle Cell disease #Sicklecell #sicklecelldisease #sicklecellanemia, #sicklecells #sickle #hematology #anemia #clinical #pediatrics #FOAM #FOAMed
Treatments for Sickle ... Cell disease ... sicklecells #sickle #hematology ... #anemia #clinical ... #pediatrics #FOAM
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... • Intrinsic RBC ... Hemoglobinopathies (e.g. sickle cell ... differential #diagnosis #hematology ... #anemia
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Mean corpuscular (cell ... acute blood loss, hemolysis ... (EPO), iron or B12 ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... , Drugs, Liver Disease ... Defects: Sickle cell ... anemia, Thalassemias ... Differential #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... loss), Vitamin B12 ... Chronic kidney disease ... . sickle cell anemia ... Production #Index #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Neutrophils - Low RBC ... RBCs in Rouleaux ... Macrocytosis, Target Cells ... • Liver Disease ... Algorithm #Causes #Hematology
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