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diagnosis algorithm systemic causes dermatology generalized management secondary aplastic ckd erythematosus hemodialysis hodgkins infections infectiousdiseases lupus lymphoma mds mycobacteria myelodysplasia
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Lesions == Macules ... Lesion / Systemic ... renal failure/uremia ... • Lymphoma • Leukemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Symptoms: • Malaise, bleeding ... • Pruritis after ... - infiltrates (anemia ... CLL -> Invade Skin ... #Hematology #Oncology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Skin Lesion - Differential ... renal failure/uremia ... • Lymphoma • Leukemia ... #generalized #dermatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
lymph nodes - Pruritus ... involved) • No leukemic ... Hepatosplenomegaly, cytopenias(bleeding ... #oncology #diagnosis ... hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... ecchymoses, mucosal bleeding ... : - Genetic lesions ... virus (EBV) • Leukemia ... #oncology #hematology
Management of Pruritus in Patients with Chronic Kidney Disease Pruritus with no primary lesions - differential diagnosis:
with no primary lesions ... - differential ... • Hematologic ... deficiency anemia ... • Malignancy (leukemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... • Hairy Cell Leukemia ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... papulosquamous lesions ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... Hodgkin lymphoma and leukemia
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Nodular or cavitary lesions ... bloodstream - seeding ... Hematologic malignancy ... Bone Marrow - Anemia ... NTM #Infections #differential
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