13 results
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypokalemia - Hypomagnesemia ... - Metabolic Alkalosis ... autosomal dominant kidney ... #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Low intake • Metabolic ... Bartter syndrome, Gitelman ... #Differential # ... potassium #low #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... Pressure: - Metabolic ... Bartter syndrome, Gitelman ... diagnosis #Algorithm #differential ... #potassium #nephrology
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Metabolic alkalosis ... #Differential # ... Diagnosis #Causes #Workup ... #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... hypomagnesemia • Metabolic ... Hypochloremic metabolic ... ratio 0.5%) Differential ... Syndrome #diagnosis #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... ↑ Aldosterone: Kidney ... Bartter syndrome, Gitelman ... urine #potassium #differential ... algorithm #diagnosis #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Kidney ... Cl- outside the kidneys ... Bartter syndrome, Gitelman ... urine #Algorithm #nephrology ... #differential #
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects in Kidney ... ascending limb Gitelman ... #Nephrology #Diagnosis ... #Differential # ... Table
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Non-anion Gap Metabolic ... Chronic progressive kidney ... aniongap #NonGap #Metabolic ... #Acidosis #differential ... diagnosis #causes #nephrology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... and Differential ... with previously stable ... disturbance, or acute kidney ... and metabolic alkalosis