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diagnosis oncology reactions rheumatology transfusion activation anemia bloodbank cryofibrinogenemia differential indications infections infectiousdiseases irradiated irradiation leukemia macrophage mas mds mycobacteria
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... result from low blood ... Anemia #oncology #hematology ... #diagnosis #management
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Transfusions: Cellular blood ... disorders (DiGeorge Syndrome ... receiving HLA-selected products ... #Indications #Hematology ... #BloodBank #Management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... due to marrow aplasia ... Blood products contain ... #diagnosis #management ... #hematology #reactions
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
work properly, leading ... unusual bruising or bleeding ... are caused by bleeding ... Causes • Anemia • Aplastic ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... , weight loss, abdominal ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
due to marrow aplasia ... Blood products contain ... coagulopathy & ↑bleeding ... #diagnosis #management ... #hematology #reactions
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
of fibrin split products ... which can plug blood ... Paradoxical spontaneous bleeding ... Antiphospholipid syndrome ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
IL-1 and IL-6, leading ... purpura to mucosal bleeding ... Fibrin degradation products ... #Diagnosis #Management ... #Hematology #Rheumatology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Milk • Food products ... Lady Windermere Syndrome ... : • Syndrome of ... Hematologic malignancy ... enzymes, diarrhea, abdominal
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