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diagnosis differential algorithm causes morphology pancytopenia rbc aplastic b12 bloodcell classification folicacid key management mcv mds microscopy myelodysplasia myelodysplastic neutropenia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology Atlas ... Microcytic - Iron-deficiency ... Liver diseases, Bleeding ... RBC #Morphology #Atlas ... #differential #hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... have hemolytic anemia ... interfered with leading ... differential #diagnosis #hematology ... #nutrition
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80 fL) • Iron Deficiency ... 80-100 fL) • Bleeding ... 100 fL) • B12 Deficiency ... • Folate Deficiency ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... Vitamin B12 • Folate ... Differential #Diagnosis #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Vitamin B12 or Folate ... deficiency, Liver ... differential #diagnosis #hematology ... #microscopy #atlas
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... ecchymoses, mucosal bleeding ... , GATA2 deficiency ... , CTLA4 deficiency ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... or folic acid deficiency ... treatments • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
of Vitamin B12 Deficiency ... pump blockers is leading ... autoantibodies (pernicious anemia ... differential #diagnosis #hematology ... #nutrition
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