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diagnosis hematology oncology differential management algorithm leukemia mds myelodysplastic bariatric bypass calculation causes chronic cll complications gastric gastronintestinal hemophilia index
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... neutropenia • Mucosal bleeding ... Treatment: • Consider ... progress to MDS or acute ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... ecchymoses, mucosal bleeding ... of CD34+ cells is ... anemia Treatment
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
maturation factor is ... marrow failure: Aplastic ... infiltration (e.g. cancer ... Index > 3: • Acute ... Production #Index #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... cell transplant is ... #hematology #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Vasculitides, IBD
Occult and Lower Gastronintestinal Bleed - Differential Diagnosis Algorithm Occult (Stool + Occult blood and/or iron deficiency
iron deficiency anemia ... • Occult UGI bleeding ... , asymptomatic IBD ... Overt Bleeding ... Diverticular bleed, • Acute
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
disease) • aPTT is ... - Acute Bleeding ... by a hemophilia treatment ... center. ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... • 75% of ALL is ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... • Aplastic Anemia ... factor (GCSF) treatments ... Syndromes #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... • Neutropenia, anemia ... Pure red cell aplasia ... microglobulin Treatment ... ’s lymphoma or acute
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