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Guidelines Directed medical therapy for Heart Failure Satyendra Dhar, MD, @DharSaty #HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
AngiotensinReceptorNeprilysinInhibitor #ACEi ... Torsemide #furosemide #bumetanide
Lisinopril - ACE inhibitor used for the treatment of hypertension and heart failure. 3rd most prescribed
Lisinopril - ACE ... inhibitor used for the treatment ... Prinivil #Qbrelis #ACEI
ACEI Antihypertensive Dose Comparison. Consider divided (BID) regimen for better pre-dose (trough) BP control for the
ACEI Antihypertensive ... the following ACEIs ... #ACEInhibitor #ACEIs
Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV =
20 mg PO/IV = Bumetanide ... #Bumex #Lasix #Bumetanide
Loop diuretic conversion - Equivalent Doses Furosemide (Lasix) 40 mg PO = Furosemide 20 mg IV =
20 mg PO/IV = Bumetanide ... #Bumex #Lasix #Bumetanide
Heart Failure (HFrEF) Treatment - GDMT for stage C For patients with Heart Failure with REDUCED
Failure (HFrEF) Treatment ... initiate them on ACEI ... maximally tolerated ACEI ... Entresto (replacing ACEI ... Pharmacology #Management #Treatment
Diuretics - summary table Thiazides and Related Diuretics: HCTZ, Chlorthalidone, Metolazone, Indapamide, Bendroflumethiazide Loop Diuretics: Furosemide, Ethacrynic
Ethacrynic acid, Bumetanide
Heart Failure Medications Summary Inhibitors of the Renin-Angiotensin System: • ACE Inhibitors: Benazepril, Captopril, Enalapril, Lisinopril, Quinapril,
Renin-Angiotensin System: • ACE ... Loop Diuretics: Bumetanide
HFrEF: Guideline Directed Medical Therapy "Must Be On" • ACEI, ARB, or ARNI AND select Beta Blockers
Must Be On" • ACEI ... before increasing ACEI ... Reducing: • ACEI
NSAID vs ACEI/ARB effects on the Kidneys Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
NSAID vs ACEI/ARB ... that NSAIDs and ACEI ... ACEI/ARB's are often
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