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anemia hemolytic causes chronic classification cold erythematosus extravascular hemolysis hodgkins intravascular leukemia lupus lymphocytic management plasmacytoma rheumatology sle solitary systemic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
(CLL) - Monoclonal ... malignancies - B-cell ... malignancies -> CLL ... significance (MGUS), CLL ... #anemia #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... can indicate disease ... lymphoproliferative disorders ... #workup #oncology ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... Consider sickle cell ... Agglutination - Cold agglutinins ... #Diagnosis #Algorithm ... #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... cold agglutin disease ... Hemoglobinopathies (e.g. sickle cell ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Workup: • Full ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Angioimmunoblastic T-cell ... the context of primary ... Frank nephritis (hypertension ... : • Chronic B-cell
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... • Plasma cell neoplasms ... MM, the plasma cell ... #Diagnosis #Workup ... #Hematology
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