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monoclonal anemia gammopathies globulin hemolytic mgus multiplemyeloma paraproteinemias protein proteingap solitary testing
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Gammopathies C - HyperCalcemia ... Look for gamma gap ... amyloidosis, solitary plasmacytoma ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... • Sickle cells ... vasculitis, malignant hypertension ... #Diagnosis #Algorithm ... #workup #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... CRAB - no anemia, hypercalcemia ... • CBC + diff • ... Oncology #Diagnosis ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... gastric tumors • Hematology ... #ProteinGap #differential ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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