11 results
oncology hemolytic management monoclonal agglutinin chronic cll cold common cvid erythematosus extravascular gammopathies globulin hemolysis hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... Retiform purpura - Protein ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... e.g. lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology ... #anemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... • Autoimmune diseases ... Degree of bandemia ... #WBC #CBC #hematology ... #pathophysiology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... Look for gamma gap ... (total protein ... plasmacytoma, POEMs syndrome ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gap (Total Protein ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... #differential # ... diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... • Symptoms of anemia ... anemia • Cold ... #hemolytic #anemia ... #hematology #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Feature A Monoclonal Protein ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... Weight loss • Anemia ... Immune hemolytic anemia ... #diagnosis #classification ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphocytosis on CBC ... cells can indicate disease ... • Neutropenia, anemia ... workup #oncology #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... • Burns • Protein-losing ... hypogammaglobulinemia #immunology #hematology
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