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management oncology algorithm chronic common cvid erythematosus extravascular hemolysis hypogammaglobulinemia immunodeficiency immunology intravascular leukemia lupus lymphocytic platelet rheumatology sle systemic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... #hemolytic #anemia ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... agglutin disease ... #differential # ... diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... agglutinins disease ... #Anemia #Differential ... #workup #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... changes), high MCV anemia ... Diagnosis #Causes ... #Workup #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... of cases) Classification ... Lymphoma Workup ... #lymphoma #diagnosis ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Neutropenia, anemia ... , thrombocytopenia ... #workup #oncology ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to 8 years Clinical ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Classification: ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... cyclophosphamide) • Hodgkin
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