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management chronic agglutinin classification cold erythematosus gap globulin hemeonc hemolytic hodgkins hypogammaglobulinemia immunology myelodysplasia myelodysplastic protein proteingap sle systemic variable
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Richter’s Syndrome ... • Sezary syndrome ... #Leukemia #diagnosis ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... • Disorder of ... lymphoma (Richter ... #Leukemia #oncology ... #hematology #hemeonc
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
CVID: Immunodeficiency ... to 8 years Clinical ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Clinical Presentation ... symptoms - most common ... fatigue, pallor, dyspnea ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Cell Leukemia ... Myeloproliferative Disease ... #diagnosis #hematology ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren syndrome ... ' syndrome in the ... lymphoproliferative syndrome ... Shrinking lung syndrome ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Cough • Dyspnea ... (NSHL) - (most common ... Workup: • Full ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... #diagnosis #hematology
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