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diagnosis management hematology neurology aids associated causes coagulation dementia diabetes diabeticketoacidosis dic differential differentiation disorder disseminated dka erectile hand intravascular
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... ATRA treatment Pathophysiology ... • Induce blast cell ... • Steroids: IV ... severe APLS, organ dysfuxtion
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
dementia Pathophysiology ... invades mononuclear cells ... CNS ○ Infected cells ... is similar to PML ... Behavioral • Motor dysfunction
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
Erectile Dysfunction ... and rigidity Endocrinologic ... Erectile Dysfunction ... -> Endothelia cell ... #Pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... 64%) • Renal dysfunction ... • Respiratory dysfunction ... Schistocytes, helmet cells ... deficiency) • HIT
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
diffusion of K+ out of cells ... hypokalemia, give IV ... KCI along with IV ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... monophasic Pathophysiology ... Autonomic Dysfunction ... Pleocytosis > 100 cells ... simplex virus, HIV
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