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differential classification management disease agglutinin anemia arteritis cold gca giantcell hemolytic hodgkins igg4 large leukemia lymphoma medium monoclonal paraproteinemias phenotypes
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... of vessel, from aorta ... left to right) aorta ... Anti-GBM = anti–glomerular ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... glomerulonephritis) • Anti-GBM ... < 30 years - Aorta ... • ANA (Suggest CTD ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Retroperitoneum and aorta ... concentration PET-CT ... conventional imaging (aorta ... No necrosis, No vasculitis ... workup #treatment #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... < 30 years • Aorta ... Arteritis): • Aorta ... pain and GN Anti-GBM ... #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Diagnosis: • hemolytic ... - Mycoplasma, EBV ... hemolytic #anemia #hematology ... #diagnosis
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... those coming off aorta ... = vasculitis vs ... in literature (NEJM ... them, but urgent rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
cells - Blood & BM ... • Cytopenia -> BM ... involvement • 30%: CNS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Mediastinal mass) • CT ... physical exam, CT ... classification #hematology ... #oncology #management
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