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diagnosis differential allergy nephrology rheumatology reactions vasculitis allergic definitions pathophysiology renal rpgn table acute acuteglomerulonephritis aki bergersdisease champs clinical clinicopathology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus ... #Types #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
of hypersensitivity ... Allergen-specific lgE causes ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... allergy #table #classification
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
: Summary Type ... conjunctivitis Type ... • Ex: Systemic Lupus ... Post-infectious glomerulonephritis ... #Classification
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... self-antigens are the cause ... : • Systemic Lupus ... antigens are the cause ... Post-infectious glomerulonephritis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification Algorithm ... #Lupus #Nephritis ... #Classification ... #differential #types
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... (e.g. systemic lupus ... #classification
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Differential Diagnosis Algorithm ... IgA, post-strep, lupus ... • Lupus glomerulonephritis ... #Causes
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). IgA Nephropathy is the most common cause of
the most common cause ... of Glomerulonephritis ... - What type of Hypersensitivity ... Relationship of complement ... PediatricNephrology #Hypersensitivity
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